Preferred Label : Personalized Genomic Vaccine 001;
NCIt synonyms : Multi-Peptide Therapeutic Vaccine 001; Personalized Peptides Plus Poly-ICLC Vaccine 001; Personalized Peptide Vaccine 001;
NCIt definition : A synthetic peptide-based, personalized cancer vaccine consisting of multiple patient-specific
tumor peptides, which are immunogenic and unique to the patient's tumor, combined
with the immunostimulant polyinosinic-polycytidylic acid stabilized with polylysine
and carboxymethylcellulose (poly-ICLC), with potential immunomodulating and antineoplastic
activities. Upon vaccination with the personalized genomic vaccine 001 (PGV001), the
peptides stimulate the host immune system to mount a specific and potent cytotoxic
T-lymphocyte (CTL) response against tumor cells expressing the neoantigens, which
results in tumor cell lysis. The adjuvant Poly-ICLC is added to boost the immune response
to the peptides and together will expand immune cells to target cancer. The adjuvant
poly-ICLC is a ligand for toll-like receptor-3 (TLR3) and induces the release of cytokines
which may help to boost the immune response against the selected neoantigens.;
Molecule name : PGV 001; PGV-001;
NCI Metathesaurus CUI : CL523769;
Origin ID : C136466;
UMLS CUI : C4526709;
Semantic type(s)
- concept_is_in_subset
