Preferred Label : Extended-release Granisetron Polymer Formulation;
NCIt synonyms : ER Granisetron Injectable Formulation; Granisetron Extended-release Polymer-based Injectable Formulation; Granisetron Extended-release Injection;
NCIt definition : An extended-release (ER), polymer-based injectable formulation containing the indazole
derivative granisetron, a selective serotonin (5-hydroxytryptamine; 5-HT) receptor
type 3 (5-HT3) antagonist, with anti-emetic activity. Upon subcutaneous administration,
granisetron is released from the polymer in a sustained manner, which is based upon
the controlled hydrolysis of the polymers, and selectively binds to and inhibits the
activity of the 5-HT3 receptors located peripherally on vagal nerve terminals and
centrally in the chemoreceptor trigger zone (CTZ) of the area postrema. By preventing
stimulation of 5-HT3 receptors, granisetron is able to suppress chemotherapy-induced
nausea and vomiting (CINV). Compared to the injection of granisetron alone, injection
of the polymer-based formulation allows for therapeutic levels of granisetron over
an extended period of time.;
Drug name : Sustol;
NCI Metathesaurus CUI : CL523732;
Origin ID : C136429;
UMLS CUI : C4528691;
Semantic type(s)
- concept_is_in_subset
