Preferred Label : Didemnin B;
NCIt synonyms : Didemnin; L-Tyrosine, N-[1-[N-[4-[[3-Hydroxy-4-[[N-[N-[1-(2-hydroxy-1-oxopropyl)- L-prolyl]-N-methyl-L-leucyl]-L-threonyl]amino]-5-methyl-1-oxoheptyl]oxy]-2,5-dimethyl-1,3-dioxohexyl]-L-leucyl]-
L-prolyl]-N,O-dimethyl-, phi-lactone (9CI); 15H-Pyrrolol[2,1-f][1,15,4,7,10,20]dioxatetraazacyclotri-cosine, Cyclic Peptide Deriv.
(9CI);
NCIt definition : A cyclic depsipeptide extracted from the Caribbean tunicate Trididemnum cyanophorum.
Didemnin B activates caspase, thereby inducing apoptosis, and prevents eukaryotic
elongation factor 2 (eEF-2)-dependent translocation, thereby inhibiting protein synthesis.
This agent also has immunosuppressive and antiviral properties. (NCI04);
UNII : OR65D8FK1B;
CAS number : 77327-05-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 77327-05-0
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G-SRS /a ;
NSC code : 333841; 325319;
Codes from synonyms : NSC0325319;
Origin ID : C1364;
UMLS CUI : C0936059;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
