Preferred Label : Diaziquone;
NCIt synonyms : Aziridinylbenzoquinone carbamic acid; 1,4-cyclohexadiene-1,4-dicarbamic acid,2,5-bis(1-aziridinyl)-3,6-dioxo,-diethyl ester; 2,5-diaziridinyl-3,6-bis(ethoxycarbonyl-amino)-1,4-benzoquinone; 2,5-bis(1-aciridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone; 2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-dicarbamic acid diethyl ester; carbamic acid, [2,5-bis(1-aziridinyl)-3,6-dioxo-1, 4-cyclohexadiene-1,4-diyl]bis-,
diethyl ester (9CI); Aziridinylbenzoquinone; Aziridinyl Benzoquinone; 1,4-cyclohexadiene-1,4-dicarbamic acid, 2, 5-bis(1-aziridinyl)-3,6-dioxo-, diethyl
ester; [2,5-bis(1-aziridinyl)-3,6-dioxo-1,4-cyclohexadiene-1,4-diyl]biscarbamic acid diethyl
ester; 2,5-bis(1-aziridinyl)-3,6-bis(ethoxycarbonylamino)-1,4-benzoquinone;
NCIt related terms : AZQ;
NCIt definition : A water-soluble, synthetic aziridinylbenzoquinone with potential antineoplastic activity.
Bioactivation of aziridinylbenzoquinone RH1 occurs through the two-electron reduction
of the quinone to the hydroquinone by the two-electron quinone reductase DT-diaphorase
(DTD). The resultant hydroquinone selectively alkylates and cross-links DNA at the
5'-GNC-3' sequence, inihibiting DNA replication, inducing apoptosis, and inhibiting
tumor cell proliferation. DTD is over-expressed in many tumors relative to normal
tissue, including lung, colon, breast and liver tumors.;
Alternative definition : NCI-GLOSS: An anticancer drug that is able to cross the blood-brain barrier and kill
cancer cells in the central nervous system.;
UNII : FQL5EUP13W;
InChIKey : WVYXNIXAMZOZFK-UHFFFAOYSA-N;
CAS number : 57998-68-2;
Molecule name : CI-904;
Chemical formula : C16H20N4O6;
NSC code : 182986;
Codes from synonyms : NSC0182986; CDR0000045178; CDR0000044389;
Origin ID : C1363;
UMLS CUI : C0113600;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- is_component_of_chemotherapy_regimen
