Preferred Label : Depudecin;
NCIt synonyms : (2R,3S,4S,5E,7S,8S,9R)-2,9- Dihydroxy-3,4;7,8-diepoxy-undeca-5,10-diene; (2S-(2R*(E(2R*(S*),3R*)),3R*(S*)))-alpha-Ethenyl-3-(2-(3-(1-hydroxyethyl)oxiranyl)ethenyl)oxiranemethanol; Oxiranemethanol, Alpha-ethenyl-3-(2-(3-(1-hydroxyethyl) oxiranyl)ethenyl)-, (2S- (2R*(E(2R*(S*),3R*)),3R*(S*)))-;
NCIt definition : Depudecin is a fungal metabolite that reverts the rounded phenotype of NIH 3T3 fibroblasts
transformed with v-ras and v-src oncogenes to the flattened phenotype of the non-transformed
parental cells. The mechanism of de-transformation induced by this agent had not been
determined. However, depudecin has been demonstrated to inhibit histone deacetylase
(HDAC) activity effectively both in vivo and in vitro.;
CAS number : 139508-73-9;
ChEBI ID : CHEBI:64143;
Codes from synonyms : 50528;
Origin ID : C1361;
UMLS CUI : C0113086;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
