Cyclopentenyl Cytosine

Preferred Label : Cyclopentenyl Cytosine;

NCIt synonyms : Cyclopentenylcytosine Triphosphate; CPE-C;

NCIt related terms : Cyclopentenylcytosine; 2(1H)-Pyrimidinone, 4-amino-1-[4, 5-dihydroxy- 3-(hydroxymethyl)-2-cyclopenten-1-yl]-;

NCIt definition : A pro-drug carbocyclic analogue of cytidine with antineoplastic and antiviral activities. Cyclopentenyl cytosine (CPEC) is converted to the active metabolite cyclopentenyl cytosine 5'-triphosphate (CPEC-TP); CPEC-TP competitively inhibits cytidine triphosphate (CTP) synthase, thereby depleting intracellular cytidine pools and inhibiting DNA and RNA synthesis. This agent may also induce differentiation of some tumor cell types. The antiviral activity of this agent is broad-spectrum.;

UNII : 69MO0NDN8K;

CAS number : 90597-22-1;

NSC code : 375575;

Codes from synonyms : NSC0375575;

Details

Origin ID

C1359;

UMLS CUI

C0111606;

Currated CISMeF NLP mapping
- cyclopentenyl cytosine [MeSH concept]
- cyclopentenyl cytosine [MeSH Supplementary Concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- cyclopentenyl cytosine [MeSH concept]
- cyclopentenyl cytosine [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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