Preferred Label : Recombinant CTAP III;
NCIt synonyms : CTAP III; Therapeutic CTAP III;
NCIt definition : Connective Tissue-Activating Peptide III is a platelet-derived growth factor that
stimulates in fibroblasts mitogenesis, extracellular matrix synthesis, glucose metabolism,
and plasminogen activator synthesis through interaction with a GPCR. It is present
in platelet granules, released by inducers of platelet aggregation, and is chemoattractant
for fibroblasts, presumably for repair. Pro-platelet basic protein is the precursor
of platelet basic protein (PBP) and CTAP III. Upon platelet activation they are released
and processed in plasma to beta-thromboglobulin and neutrophil-activating peptide-2.
The thrombocidins TC1 and TC2 are variants of NAP2 and CTAP III, respectively. TC1
and TC2 differ from NAP2 and CTAP III by their bactericidal and fungicidal properties,
which apparently do not involve pore formation. (from OMIM 121010 and NCI);
Origin ID : C1358;
UMLS CUI : C1523977;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
