Preferred Label : Grape Seed Extract Supplement;
NCIt synonyms : GSE Supplement; GSE;
NCIt definition : An orally bioavailable dietary supplement composed of an extract from grape seeds
containing high amounts of polyphenols, particularly lower proanthocyanidin oligomers
(OPCs) and catechins, with antioxidant and chemopreventive activities. Upon administration,
the active components in the grape seed extract (GSE) scavenge free radicals, protect
against oxidation of low-density lipoprotein (LDL), and inhibit cell damage due to
reactive oxygen species (ROS). This inhibits oxidative stress and protects against
DNA damage. GSE also inhibits enzymes involved in inflammation, cell replication and
DNA synthesis, and induces the expression of anti-oxidant enzymes. This may inhibit
growth and induce apoptosis of cancer cells.;
NCI Metathesaurus CUI : CL522986;
Origin ID : C135631;
UMLS CUI : C4522134;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
