Preferred Label : Liposomal Vinorelbine Tartrate;
NCIt definition : A formulation of the tartrate salt form of vinorelbine, a semisynthetic vinca alkaloid,
encapsulated within liposomes, with potential antineoplastic activity. Upon intravenous
administration, vinorelbine binds to tubulin within tumor cells and prevents the formation
of the mitotic spindle, resulting in cell cycle arrest, induction of apoptosis and
an inhibition of tumor cell growth. Compared to the administration of vinorelbine
alone, the liposomal formulation improves drug penetration into tumors and decreases
drug clearance, thereby increasing vinorelbine's efficacy while lowering the toxicity
profile.;
Molecule name : TLC-178;
NCI Metathesaurus CUI : CL522975;
Origin ID : C135619;
UMLS CUI : C4525943;
Semantic type(s)
- concept_is_in_subset
- has_target
