Preferred Label : Polymyxin-B Immobilized Fiber PMX-20R;
NCIt synonyms : PMX-20R; PMX Cartridge;
NCIt definition : A cartridge containing a polystyrene-based composite woven fiber that is covalently
attached to the anti-microbial cyclic cationic polypeptide antibiotic polymyxin-B
(PMX) and can potentially be used for hemoperfusion purposes. Upon extracorporeal
treatment, a patient's blood flows through the fibers in the polymyxin-B immobilized
fiber PMX-20R cartridge and the circulating endotoxins from the blood are selectively
adsorbed by PMX, which has positively charged amino groups that bind to the negatively
charged site in the lipid A portion of the lipopolysaccharide (LPS) layer of the bacterial
cell membrane. This removes endotoxins from the blood and, upon administration of
the blood back into the patient, helps treat or reduce the incidence of endotoxemia
and sepsis.;
Drug name : Toraymyxin;
NCI Metathesaurus CUI : CL522971;
Origin ID : C135615;
UMLS CUI : C4525939;
Semantic type(s)
- concept_is_in_subset
