Preferred Label : Neural Stem Cells-expressing CRAd-S-pk7;
NCIt synonyms : NSCs loaded with CRAd-S-pk7; NSC-CRAd-S-pk7 Virotherapeutic; NSC-CRAd-S-pk7; CRAd-S-pk7 loaded NSCs; SC-CRAd-Survivin-pk7;
NCIt definition : Neural stem cells (NSCs) that are transfected with the gliomatropic oncolytic adenovirus
(OV) CRAd-S-pk7, a conditionally replicative oncolytic adenoviral (CRAd) vector that
contains the tumor-specific survivin promoter (S) and a fiber protein polylysine modification
(pk7), with potential antineoplastic activity. Upon intracerebral administration of
NSC loaded with CRAd-S-pk7, the NSCs preferentially migrate towards tumor cells, and
the polylysine moiety of the modified fiber protein expressed by the viral vector
specifically targets and binds to tumor-specific heparan sulfate proteoglycans. Subsequently,
the virus can infect the tumor cells and viral replication is initiated because E1
gene expression is controlled by the tumor-specific promoter for survivin. This results
in the specific lysis of the glioma cells. The pk7 fiber modification and the survivin
promoter enable tumor-specific infectivity, and transcriptional targeting and preferential
replication in glioma cells, while sparing the surrounding normal brain parenchyma.
The pK7 is comprised of a heparan sulfate binding domain incorporated into the fiber
protein of the adenovirus.;
NCI Metathesaurus CUI : CL522968;
Origin ID : C135612;
UMLS CUI : C4525936;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
