NCIt synonyms : Diphenoxylate Hydrochloride and Atropine Sulfate;
NCIt definition : A formulation containing the hydrochloride salt form of diphenoxylate, a synthetic
opioid of the phenylpiperidine class, and the sulfate salt form of the anticholinergic
agent atropine, with antidiarrheal activity. Upon oral administration, diphenoxylate
acts on opioid receptors in the gastrointestinal (GI) tract, thereby decreasing GI
motility, prolonging transit time, and preventing diarrhea. Through its anticholinergic
effects, atropine prevents deliberate over-usage of diphenoxylate by triggering very
unpleasant side effects (SEs), such as severe weakness and nausea.;
Currated CISMeF NLP mapping