Preferred Label : Alloantigen-specific Allogeneic Type 1 Regulatory T Cells T-allo10;
NCIt synonyms : T-allo10 Cells; Donor-derived Host Alloantigen-specific IL-10 Anergized T Cells; T-allo10; Alloantigen-specific Type 1 Tregs T-allo10; Alloantigen-specific TR1 Cells Allo10;
NCIt definition : A preparation of allogeneic CD4 cells that were ex vivo stimulated with alloantigens,
which involves exposing the cells to host antigen-presenting cells (APCs), in the
presence of the immunomodulatory cytokine interleukin-10 (IL-10), with potential to
prevent graft-versus-host disease (GvHD). The stimulation of the CD4 cells by exposure
to alloantigens plus IL-10 induces the differentiation of alloantigen-specific type
1 T regulatory (TR1) cells, which are hyporesponsive to the alloantigens. Upon infusion
of T-allo10 and prior to donor hematopoietic stem cell transplantation (HSCT), the
alloantigen-specific type 1 regulatory T-cells are tolerant to the alloantigens and
suppress alloreactive immune responses by donor CD4 and CD8 T-cells. This may ultimately
prevent GvHD. IL-10 plays a key role in controlling inflammation, down-regulating
immune responses, and inducing immunological tolerance. IL-10 induces both a long
lasting antigen specific T-cell anergy and the differentiation of TR1 cells.;
NCI Metathesaurus CUI : CL522354;
Origin ID : C134838;
UMLS CUI : C4525410;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
