Empegfilgrastim

Preferred Label : Empegfilgrastim;

NCIt synonyms : 1-(N-(4-(omega-Methoxypoly(oxyethylene))butyl)-L-methionine))human granulocyte colony-stimulating factor (pluripoietin);

NCIt definition : A long-acting form and covalent conjugate of recombinant human granulocyte colony-stimulating factor (G-CSF) filgrastim with 30 kDa polyethylene glycol (PEG), with potential hematopoietic activity. Upon administration, empegfilgrastim acts similarly to endogenous G-CSF and binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. Therefore, this agent may prevent the incidence and shorten the duration of chemotherapy-induced neutropenia. Conjugation of the cytokine with a PEG molecule significantly increases this agent's therapeutic half-life compared to filgrastim.;

UNII : F0B69ZZ07A;

CAS number : 1192706-53-8;

Molecule name : BCD 017; BCD-017;

NCI Metathesaurus CUI : CL522347;

Details

Origin ID

C134829;

UMLS CUI

C4301614;

Currated CISMeF NLP mapping
- Empegfilgrastim [ICD-11 Extension code]
- Empegfilgrastim [SMS substance]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- empegfilgrastim [ATC Code]
Validated automatic mappings to BTNT
- empegfilgrastim [ATC Code]
chemical_or_drug_affects_cell_type_or_tissue
- Hematopoietic Stem Cell [NCIt concept]
chemical_or_drug_affects_gene_product
- GM-CSF Receptor [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Positive Regulation of Cell Differentiation [NCIt concept]
- Receptor Activation Process [NCIt concept]
- Stimulation of Cell Proliferation [NCIt concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients