Preferred Label : Mirasol-treated Allogeneic Platelets;
NCIt synonyms : Allogeneic Mirasol PRT-treated Platelets; Allogeneic Mirasol Platelets; Allogeneic MIR PLTs;
NCIt definition : A preparation of allogeneic platelets that have been treated with Mirasol, a proprietary
pathogen reduction technology (PRT) system, and can potentially be used to improve
symptoms associated with thrombocytopenia. Upon apheresis, platelets are treated with
the patented PRT system, which includes treatment of the platelets with riboflavin
(vitamin B2) and broad-spectrum ultraviolet (UV) light. The treatment causes irreversible
changes to the RNA and DNA of a broad range of pathogens, including viruses, bacteria,
parasites and white blood cells (WBCs), which prevents them from replicating and causing
disease. After ex vivo treatment and upon transfusion, the Mirasol-treated allogeneic
platelets may reduce thrombocytopenia and prevent bleeding. By preventing the replication
of contaminating pathogens, Mirasol treatment improves transfusion safety. Inactivation
of WBCs may reduce transfusion reactions and immunological complications in patients.;
NCI Metathesaurus CUI : CL522172;
Origin ID : C134620;
UMLS CUI : C4525267;
Semantic type(s)
- concept_is_in_subset
