Valrubicin - CISMeF

Preferred Label : Valrubicin;

NCIt synonyms : N-Trifluoroacetyladriamycin-14-valerate;

NCIt related terms : AD 32;

NCIt definition : A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin. With a mechanism of action that appears to differ from doxorubicin, valrubicin is converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently, DNA replication and repair and RNA and protein synthesis are inhibited and the cell cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic than doxorubicin when administered systemically; applied topically, this agent shows excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino group of the glycoside and the valerate moiety appear to result in a lipophilicity that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations.;

Alternative definition : NCI-GLOSS: A drug used to treat bladder cancer that does not respond to BCG (Bacillus Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic.;

UNII : 2C6NUM6878;

InChIKey : ZOCKGBMQLCSHFP-KQRAQHLDSA-N;

CAS number : 56124-62-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 56124-62-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Valtaxin; Valstar;

Molecule name : AD 32; AD-32;

Chemical formula : C34H36F3NO13;

NSC code : 246131;

Codes from synonyms : CDR0000390320; CDR0000045168; NSC0246131; 528;

Details

Origin ID

C1340;

UMLS CUI

C0068314;

Automatic exact mappings (from CISMeF team)
- Valrubicin [ICD-11 Extension code]
Currated CISMeF NLP mapping
- Valrubicin (substance) [SNOMED CT concept]
- valrubicin [MeSH concept]
- valrubicin [MeSH Supplementary Concept]
See also inter- (CISMeF)
- Product containing valrubicin (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing valrubicin (medicinal product) [SNOMED CT concept]
- Valrubicin (substance) [SNOMED CT concept]
- valrubicin [ATC Code]
- valrubicin [MeSH concept]
- valrubicin [MeSH Supplementary Concept]
Validated automatic mappings to BTNT
- valrubicin [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Valrubicin Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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