NCIt definition : A semisynthetic derivative of the antineoplastic anthracycline antibiotic doxorubicin.
With a mechanism of action that appears to differ from doxorubicin, valrubicin is
converted intracytoplasmically into N-trifluoroacetyladriamycin, which interacts with
topoisomerase II, stabilizing the complex between the enzyme and DNA; consequently,
DNA replication and repair and RNA and protein synthesis are inhibited and the cell
cycle is arrested in the G2 phase. In addition, this agent accumulates in the cell
cytoplasm where it inhibits protein kinase C (PKC). Valrubicin is less cardiotoxic
than doxorubicin when administered systemically; applied topically, this agent shows
excellent tissue penetration. Structurally, the trifluoro-acetyl moiety on the amino
group of the glycoside and the valerate moiety appear to result in a lipophilicity
that is greater than of doxorubicin, resulting in increased intracytoplasmic concentrations.;
Alternative definition : NCI-GLOSS: A drug used to treat bladder cancer that does not respond to BCG (Bacillus
Calmette Guerin). It is an anthracycline and is a type of antitumor antibiotic.;
UNII : 2C6NUM6878;
InChIKey : ZOCKGBMQLCSHFP-KQRAQHLDSA-N;
CAS number : 56124-62-0;
Drug name : Valtaxin; Valstar;
Molecule name : AD 32; AD-32;
Chemical formula : C34H36F3NO13;
NSC code : 246131;
Codes from synonyms : CDR0000390320; CDR0000045168; NSC0246131; 528;