Preferred Label : 3D-expanded Placenta-derived Cells PLX-R18;
NCIt synonyms : PLacental eXpanded-R18; PLX-R18 Cells;
NCIt definition : A population of proprietary, off-the-shelf, three-dimensional (3D)-expanded, allogeneic
placenta-derived stromal cells that can potentially be used to increase hematopoietic
recovery from hematological disorders or after a hematopoietic stem cell transplant
(HSCT). Upon intramuscular (IM) injection of placental expanded (PLX)-R18, these cells
secrete a range of specific hematopoietic, regenerative proteins depending on their
in vivo environment. The secreted proteins are involved in maintenance, renewal, proliferation,
differentiation, and mobilization of hematopoietic progenitor cells (HPCs), and include,
but are not limited to, granulocyte colony-stimulating factor (GCSF), monocyte chemoattractant
protein-1 (MCP-1/CCL2), MCP-3 (CCL7), interleukin-6 (IL-6), and IL-8. This increases
the number of colony-forming hematopoietic progenitors in the bone marrow, regenerates
the bone marrow hematopoietic cells, and elevates and restores blood cell production.;
Molecule name : PLX R18; PLX-R18; PLX RAD;
NCI Metathesaurus CUI : CL521744;
Origin ID : C133823;
UMLS CUI : C4524911;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
