Preferred Label : Anti-AG7 Antibody Drug Conjugate AbGn-107;
NCIt synonyms : Anti-AG7 ADC AbGn-107; ADC AbGn-107;
NCIt definition : An antibody drug conjugate (ADC) composed of a monoclonal antibody that targets the
tumor-associated antigen (TAA) AG7 and is linked, through a hydrophilic, self-immolative
linker, to a proprietary cytotoxic payload, with potential antineoplastic activity.
Upon administration of AbGn-107 the antibody moiety targets and binds to the AG7 antigen
expressed on a variety of cancer cells. Upon binding and internalization, the linker
is cleaved and the payload is released, binds to tubulin, inhibits tubulin polymerization
and kills the AG7-expressing tumor cells.;
Molecule name : Ab1-18Hr1; AbGn-107;
NCI Metathesaurus CUI : CL521740;
Origin ID : C133818;
UMLS CUI : C4524907;
Semantic type(s)
- concept_is_in_subset
