Preferred Label : Arsenic Trioxide Capsule Formulation ORH 2014;
NCIt synonyms : Arsenic Trioxide Formulation ORH 2014; Oral Arsenic Trioxide Formulation; As2O3 Formulation ORH 2014;
NCIt definition : An orally bioavailable capsule formulation of the inorganic toxic compound arsenic
trioxide (As2O3), with potential antineoplastic activity. Although the mechanism of
action (MoA) of As2O3 is not well understood, upon oral administration of ORH 2014,
As2O3 appears to bind to DNA, prevent DNA synthesis, and cause DNA fragmentation,
which leads to an induction of apoptosis in proliferating cells, including tumor cells.
In addition, As2O3 causes damage to and induces degradation of the promyelocytic leukemia
protein/retinoic acid receptor-alpha (PML/RARa) fusion protein, and inhibits the activity
of the enzyme thioredoxin reductase.;
Molecule name : ORH 2014;
NCI Metathesaurus CUI : CL520496;
Origin ID : C133720;
UMLS CUI : C4524848;
Semantic type(s)
- concept_is_in_subset
