Aumolertinib - CISMeF

Preferred Label : Aumolertinib;

NCIt synonyms : EGFR Tyrosine Kinase Inhibitor HS-10296; Almonertinib;

NCIt definition : An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity. Upon administration, aumolertinib binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation, inhibits the tyrosine kinase activity of EGFR T790M, prevents EGFR T790M-mediated signaling and leads to cell death in EGFR T790M-expressing tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types, plays a key role in tumor cell proliferation and tumor vascularization.;

UNII : T4RS462G19;

InChIKey : DOEOECWDNSEFDN-UHFFFAOYSA-N;

CAS number : 1899921-05-1;

Molecule name : HS-10296; EQ143; HS 10296;

NCI Metathesaurus CUI : CL521177;

Codes from synonyms : 12637;

Details

Origin ID

C133691;

UMLS CUI

C5446308;

Currated CISMeF NLP mapping
- aumolertinib [MeSH concept]
- aumolertinib [MeSH Supplementary Concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- aumolertinib [MeSH Supplementary Concept]
- aumolertinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_salt_form
- Aumolertinib Mesylate [NCIt concept]
has_target
- EGFR NP_005219.2:p.T790M [NCIt concept]
is_free_acid_or_base_form_of
- Aumolertinib Mesylate [NCIt concept]

Keyword's position in hierarchy(ies) :

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