Cladribine - CISMeF

Preferred Label : Cladribine;

NCIt synonyms : Cladribina; CdA; 2-Chloro-2-Deoxyadenosine; 2CDA; 2-Chlorodeoxyadenosine; 2-CdA;

NCIt definition : A purine nucleoside antimetabolite analogue. Cladribine triphosphate, a phosphorylated metabolite of cladribine, incorporates into DNA, resulting in single-strand breaks in DNA, depletion of nicotinamide adenine dinucleotide (NAD) and adenosine triphosphate (ATP), and apoptosis. Because this agent is resistant to adenosine deaminase, an enzyme that inactivates some antineoplastic agents, it is selectively toxic to lymphocytes and monocytes which exhibit little deoxynucleotide deaminase activity. (NCI04);

Alternative definition : NCI-GLOSS: An anticancer drug that belongs to the family of drugs called antimetabolites.;

NCIt note : http://www.cancercare.on.ca/pdfdrugs/Cladribi.pdf;

UNII : 47M74X9YT5;

InChIKey : PTOAARAWEBMLNO-KVQBGUIXSA-N;

CAS number : 4291-63-8;

Drug name : Leustatine; Leustat; Leustatin;

Molecule name : RWJ-26251;

Chemical formula : C10H12ClN5O3;

NSC code : 105014-F; 105014;

ChEBI ID : CHEBI:567361;

Codes from synonyms : CDR0000045341; 107;

Details

Origin ID

C1336;

UMLS CUI

C0092801;

Automatic exact mappings (from CISMeF team)
- 2-chloro-3'-deoxyadenosine [MeSH concept]
- 2-chloro-3'-deoxyadenosine [MeSH Supplementary Concept]
False automatic mappings
- Anemia, congenital dyserythropoietic, type II [OMIM Phenotype]
- Anemia, congenital dyserythropoietic, type ia [OMIM Phenotype]
- Anemia, congenital dyserythropoietic, type iiia [OMIM Phenotype]
- Congenital dyserythropoietic anaemia [ICD-11 Category]
- Congenital dyserythropoietic anemia [ORDO Disease]
- Congenital dyserythropoietic anemia (disorder) [SNOMED CT concept]
- Corneal dystrophy, avellino type [OMIM Phenotype]
- Cytidine deaminase [OMIM gene]
- anemia, dyserythropoietic, congenital [MeSH Descriptor]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Cladribine (substance) [SNOMED CT concept]
- Product containing cladribine (medicinal product) [SNOMED CT concept]
- cladribine [ATC Code]
- cladribine [ATC Code]
- cladribine [MeSH concept]
- cladribine [MeSH Descriptor]
Validated automatic mappings to BTNT
- cladribine [ATC Code]
- cladribine [ATC Code]
concept_is_in_subset
- AML Authorized Value Terminology [NCIt concept]
- AML Total Dose Table [NCIt concept]
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Bryostatin 1/Cladribine [NCIt concept]
- CLAG Regimen [NCIt concept]
- CLAG-M Regimen [NCIt concept]
- Chlorambucil/Cladribine [NCIt concept]
- Cladribine Regimen [NCIt concept]
- Cladribine/Cyclophosphamide/Prednisone [NCIt concept]
- Cladribine/Cytarabine [NCIt concept]
- Cladribine/Etoposide [NCIt concept]
- Cladribine/High-dose Cytarabine/Idarubicin/Filgrastim Regimen [NCIt concept]
- Cladribine/Idarubicin [NCIt concept]
- Cladribine/Rituximab [NCIt concept]
- Cladribine/Rituximab Regimen [NCIt concept]
- IDA-FLAG/Venetoclax Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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