Preferred Label : Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8;
NCIt related terms : Stage IV; Stage IV Head and Neck Squamous Cell Cancer;
NCIt definition : Stage IV includes: (T1, N2, M0); (T2, N2, M0); (T3, N2, M0); (Any T, N3, M0); (T4,
Any N, M0); (Any T, Any N, M1). T1: Tumor smaller than 2 cm in greatest dimension.
T2: Tumor 2 cm or larger, but smaller than 4 cm in greatest dimension. T3: Tumor 4
cm or larger in greatest dimension or minor bone erosion or perineural invasion or
deep invasion. Deep invasion is defined as invasion beyond the subcutaneous fat or
larger than 6 mm; perineural invasion for T3 classification is defined as tumor cells
within the nerve sheath of a nerve lying deeper than the dermis or measuring 0.1 mm
or larger in caliber, or presenting with clinical or radiographic involvement of named
nerves without skull base invasion or transgression. T4: Tumor with gross cortical
bone/marrow, skull base invasion and/or skull base foramen invasion. N2: Metastasis
in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(
); or metastasis in a single ipsilateral lymph node larger than 3 cm but not larger
than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral
lymph nodes, none larger than 6 cm in greatest dimension and ENE(-); or metastases
in bilateral or contralateral lymph nodes, none larger than 6 cm in greatest dimension
and ENE(-). N3: Metastasis in a lymph node larger than 6 cm in greatest dimension
and ENE(-); or metastasis in a single ipsilateral lymph node larger than 3 cm in greatest
dimension and ENE( ); or metastases in multiple ipsilateral, contralateral, or bilateral
lymph nodes, any with ENE( ). M0: No distant metastasis. M1: Distant metastasis. (AJCC
8th ed.);
Neoplastic status : Malignant;
NCI Metathesaurus CUI : CL520961;
Origin ID : C133259;
UMLS CUI : C4524524;
Automatic exact mappings (from CISMeF team)
- Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
