Preferred Label : mTOR Inhibitor GDC-0349;
NCIt synonyms : (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea;
NCIt related terms : GDC-0349;
NCIt definition : An orally bioavailable, ATP-competitive, tetrahydroquinazoline (THQ)-based inhibitor
of the mammalian target of rapamycin (mTOR) with potential antineoplastic activity.
Upon administration, GDC-0349 selectively binds to and inhibits the activity of mTOR,
which may result in both the induction of tumor cell apoptosis and a decrease in tumor
cell proliferation. mTOR, a serine/threonine kinase belonging to the phosphatidylinositol-3
(PI3K) kinase-related kinase (PIKK) family, plays an important role in the PI3K/Akt/mTOR
signaling pathway that regulates cell growth and proliferation, and its expression
or activity is frequently dysregulated in human cancers.;
UNII : 579255I6O9;
CAS number : 1207360-89-1;
Molecule name : GDC-0349; RG7603; GDC 0349;
NCI Metathesaurus CUI : CL433839;
Origin ID : C133227;
UMLS CUI : C4507630;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
