Preferred Label : Stage IV Laryngeal Cancer AJCC v8;
NCIt synonyms : Stage IV Laryngeal Carcinoma AJCC v8;
NCIt related terms : Stage IV Laryngeal Throat Cancer;
NCIt definition : Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0);
(T3, N2, M0); (T4a, N2, M0); IVB: (Any T, N3, M0); (T4b, Any N, M0); IVC: (Any T,
Any N, M1). T4a: Supraglottis: Moderately advanced local disease. Tumor invades through
the outer cortex of the thyroid cartilage and/or invades tissues beyond the larynx
(e.g., trachea, soft tissues of neck including deep extrinsic muscle of the tongue,
strap muscles, thyroid, or esophagus). Glottis: Moderately advanced local disease.
Tumor invades through the outer cortex of the thyroid cartilage and/or invades tissues
beyond the larynx (e.g., trachea, cricoid cartilage, soft tissues of neck including
deep extrinsic muscle of the tongue, strap muscles, thyroid, or esophagus). Subglottis:
Moderately advanced local disease. Tumor invades cricoid or thyroid cartilage and/or
invades tissues beyond the larynx (e.g., trachea, soft tissues of neck including deep
extrinsic muscles of the tongue, strap muscles, thyroid, or esophagus). T3: Supraglottis:
Tumor is limited to larynx with vocal cord fixation and/or invades any of the following:
postcricoid area, preepiglottic space, paraglottic space, and/or inner cortex of thyroid
cartilage. Glottis: Tumor is limited to the larynx with vocal cord fixation and /or
invades the paraglottic space, and/or inner cortex of the thyroid cartilage. Subglottis:
Tumor is limited to the larynx with vocal cord fixation and/or invades the paraglottic
space and/or inner cortex of the thyroid cartilage. T1: Supraglottis: Tumor is limited
to one subsite of supraglottis with normal vocal cord mobility. Glottis: Tumor is
limited to the vocal cord(s) (may involve anterior or posterior commissure) with normal
mobility. Subglottis: Tumor is limited to the subglottis. T2: Supraglottis: Tumor
invades the mucosa of more than one adjacent subsite of supraglottis or glottis or
region outside the supraglottis (e.g., mucosa of base of the tongue, vallecula, medial
wall of pyriform sinus) without fixation of the larynx. Glottis: Tumor extends to
supraglottis and/or subglottis, and/or with impaired vocal cord mobility. Subglottis:
Tumor extends to vocal cord(s) with normal or impaired mobility. T4b: Supraglottis:
Very advanced local disease. Tumor invades prevertebral space, encases carotid artery,
or invades mediastinal structures. Glottis: Very advanced local disease. Tumor invades
prevertebral space, encases carotid artery, or invades mediastinal structures. Subglottis:
Very advanced local disease. Tumor invades prevertebral space, encases carotid artery,
or invades mediastinal structures. N0: No regional lymph node metastasis. N1: Metastasis
in a single ipsilateral lymph node, 3 cm or less in greatest dimension and ENE(-).
N2: Metastasis in a single ipsilateral lymph node, 3 cm or less in greatest dimension
and ENE( ); or metastasis in a single ipsilateral lymph node, more than 3 cm but not
more than 6 cm in greatest dimension and ENE(-); or metastases in multiple ipsilateral
lymph nodes, none more than 6 cm in greatest dimension and ENE(-); or metastasis in
bilateral or contralateral lymph nodes, none more than 6 cm in greatest dimension
and ENE(-). N3: metastasis in a lymph node, more than 6 cm in greatest dimension and
ENE(-); or metastasis in a single ipsilateral lymph node, more than 3 cm in greatest
dimension and ENE( ); or metastases in multiple ipsilateral, contralateral, or bilateral
lymph nodes and any with ENE( ). M0: No distant metastasis. M1: distant metastasis.
(AJCC 8th ed.);
Neoplastic status : Malignant;
NCI Metathesaurus CUI : CL520509;
Origin ID : C133161;
UMLS CUI : C4521633;
Disease excludes abnormal cell
Has associated anatomic sites
Semantic type(s)
concept_is_in_subset
disease_excludes_finding
disease_has_abnormal_cell
disease_has_finding
disease_has_normal_cell_origin
disease_has_normal_tissue_origin
disease_has_primary_anatomic_site
disease_is_stage