Gelonin - CISMeF

Preferred Label : Gelonin;

NCIt synonyms : GEL Protein, Gelonium multiflorum; rGel; Ribosome-inactivating Protein Gelonin, Gelonium multiflorum;

NCIt definition : A class I ribosome-inactivating protein (RIP) and toxin derived from the seeds of the plant Gelonium multiflorum. Gelonin (rGel) exerts N-glycosidase activity on the 28S ribosomal RNA (rRNA) unit of eukaryotic ribosomes by cleaving out adenine at the 4324 site, which depurinates rRNA, inactivates ribosomes, inhibits protein synthesis, and results in cell death. Used as the toxin moiety of certain immunotoxins and linked to antibodies specific for a tumor-associated antigen (TAA), gelonin can be targeted to and induce specific cytotoxicity in tumor cells expressing the TAA.;

CAS number : 75037-46-6;

Details

Origin ID

C133021;

UMLS CUI

C0061184;

Automatic exact mappings (from CISMeF team)
- GEL protein, gelonium multiflorum [MeSH concept]
- GEL protein, gelonium multiflorum [MeSH Supplementary Concept]
- rRNA N-glycosylase activity [GO term]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- GEL protein, gelonium multiflorum [MeSH Supplementary Concept]
- GEL protein, gelonium multiflorum [MeSH concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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