Preferred Label : Proapoptotic Sulindac Analog CP-461;
NCIt synonyms : 1H-Indene-3-acetamide, 5-Fluoro-2-methyl-N-(phenylmethyl)-1-(4-pyridinylmethylene)-,
Monohydrochloride, (1Z)-;
NCIt related terms : CP-461;
NCIt definition : An orally bioavailable second-generation selective apoptotic antineoplastic drug (SAAND)
and analog of the nonsteroidal anti-inflammatory drug (NSAID) sulindac, with potential
pro-apoptotic and antineoplastic activities. Upon administration, CP-461 specifically
binds to and blocks the activity of cyclic guanosine monophosphate-phosphodiesterase
(cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway. Inhibition
of cGMP-PDE permits the apoptotic signal pathway to proceed unopposed, resulting in
apoptotic cell death. cGMP-PDE is overexpressed in a variety of cancer cell types;
therefore, CP-461 selectively induces apoptosis in cancer cells, with minimal or no
effect in healthy cells.;
UNII : 68OJX9I7DT;
InChIKey : KGXPDNOBLLACKL-BWLGBDCWSA-N;
CAS number : 227619-96-7;
Molecule name : CP-461; CP 461; OSI 461; CEL 031;
Origin ID : C133019;
UMLS CUI : C1101538;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
