Preferred Label : Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8;
NCIt related terms : Stage IV Oropharyngeal (p16-Negative) Throat Cancer;
NCIt definition : Stage IV includes: IVA: (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0);
(T3, N2, M0); (T4a, N2, M0); IVB: (Any T, N3, M0); (T4b, Any N, M0); IVC: (Any T,
Any N, M1). T4a: Moderately advanced local disease. Tumor invades the larynx, extrinsic
muscle of tongue, medial pterygoid, hard palate, or mandible. Mucosal extension to
lingual surface of epiglottis from primary tumors of the base of the tongue and vallecula
does not constitute invasion of the larynx. T1: Tumor 2 cm or smaller in greatest
dimension. T2: Tumor larger than 2 cm but not larger than 4 cm in greatest dimension.
T3: Tumor larger than 4 cm in greatest dimension or extension to lingual surface of
epiglottis. T4b: Very advanced local disease. Tumor invades lateral pterygoid muscle,
pterygoid plates, lateral nasopharynx, or skull base or encases carotid artery. N0:
No regional lymph node metastasis. N1: Tumor with metastasis in a single ipsilateral
lymph node, 3 cm or smaller in greatest dimension and ENE (-). N2: Tumor with metastasis
in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(
); or larger than 3 cm but not larger than 6 cm in greatest dimension and ENE(-);
or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm in greatest
dimension and ENE(-); or metastases in bilateral or contralateral lymph nodes, none
larger than 6 cm in greatest dimension and ENE(-). N3: Tumor with metastasis in a
lymph node larger than 6 cm in greatest dimension and ENE(-); or metastasis in a single
ipsilateral lymph node larger than 3 cm in greatest dimension and ENE( ); or metastases
in multiple ipsilateral, contralateral, or bilateral lymph nodes any with ENE( ).
M0: No distant metastasis. M1: Distant metastasis. (AJCC 8th ed.);
Neoplastic status : Malignant;
NCI Metathesaurus CUI : CL520964;
Origin ID : C132999;
UMLS CUI : C4331335;
Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
