Preferred Label : Gallium Ga 68-NODAGA-E(c[RGDyK])2;
NCIt synonyms : 68Ga-NODAGA-E(c[RGDyK])2;
NCIt definition : A radiopharmaceutical agent composed of a dimeric cyclic arginine-glycine-aspartic
acid (RGD)-based peptide (c[RGDyK]) and labeled, via the chelating agent 1,4,7-triazacyclononane,1-glutaric
acid-4,7-acetic acid (NODAGA), with gallium Ga 68, with potential alphaVbeta3 (aVb3)
integrin imaging activity upon positron emission topography (PET) or single photon
emission computed tomography (SPECT). After intravenous administration of gallium
Ga 68-NODAGA-E(c[RGDyK])2, the cyclic RGD moiety targets and binds to aVb3 integrin
which is expressed on the cell membrane of tumor cells and tumor-resident endothelial
cells. Upon imaging, aVb3 integrin-expressing cells can be visualized and expression
levels can be quantified. This can be used to assess response to anti-angiogenic treatment.
aVb3 integrin is overexpressed on certain tumor cells and tumor-resident endothelial
cells, while minimally or not expressed on healthy, normal cells; aVb3 integrin plays
a key role in angiogenesis, tumor proliferation and survival.;
NCI Metathesaurus CUI : CL520664;
Origin ID : C132993;
UMLS CUI : C4330033;
Semantic type(s)
- concept_is_in_subset
