Preferred Label : Stage IV Lip and Oral Cavity Cancer AJCC v8;
NCIt synonyms : Stage IV Lip and Oral Cavity Carcinoma AJCC v8;
NCIt related terms : Stage IV Lip and Oral Cavity Cancer;
NCIt definition : Stage IV includes: IVA (T4a, N0, M0); (T4a, N1, M0); (T1, N2, M0); (T2, N2, M0); (T3,
N2, M0); (T4a, N2, M0); IVB (Any T, N3, M0); (T4b, Any N, M0); IVC (Any T, Any N,
M1). T4a (lip): Tumor invades through cortical bone or involves the inferior alveolar
nerve, floor of mouth, or skin of face (i.e., chin or nose). T4a (oral cavity): Tumor
invades adjacent structures only (e.g., through cortical bone of the mandible or maxilla,
or involves the maxillary sinus or skin of face). Note: Superficial erosion of bone/tooth
socket (alone) by a gingival primary is not sufficient to classify a tumor as T4.
T1: Tumor size 2 cm or less in greatest dimension and 5 mm or less DOI. T2: Tumor
size 2 cm or less in greatest dimension, DOI greater than 5 mm and equal or less than
10 mm or tumor greater than 2 cm but 4 cm or less in greatest dimension and 10 mm
or less DOI. T3: Tumor size greater than 4 cm or any tumor greater than 10 mm DOI.
T4b: Tumor invades masticator space, pterygoid plates, or skull base and/or encases
the internal carotid artery. N0: No regional lymph node metastasis. N1: Metastasis
in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension and ENE(-).
N2: Metastasis in a single ipsilateral lymph node, 3 cm or smaller in greatest dimension
and ENE( ); or larger than 3 cm but not larger than 6 cm in greatest dimension and
ENE (-); or metastases in multiple ipsilateral lymph nodes, none larger than 6 cm
in greatest dimension and ENE(-); or metastases in bilateral or contralateral lymph
nodes, none larger than 6 cm in greatest dimension, ENE(-). N3: Metastasis in a lymph
node larger than 6 cm in greatest dimension and ENE (-); or in a single ipsilateral
lymph node larger than 3 cm in greatest dimension and ENE( ); or metastases in multiple
ipsilateral, contralateral or bilateral lymph nodes any with ENE( ). M0: No distant
metastasis. M1: Distant metastasis. (AJCC 8th Ed.);
Neoplastic status : Malignant;
NCI Metathesaurus CUI : CL520510;
Origin ID : C132732;
UMLS CUI : C4331333;
Automatic exact mappings (from CISMeF team)
- Disease excludes abnormal cell
- Has associated anatomic sites
- Semantic type(s)
- concept_is_in_subset
- disease_excludes_finding
- disease_has_abnormal_cell
- disease_has_finding
- disease_has_normal_cell_origin
- disease_has_normal_tissue_origin
- disease_has_primary_anatomic_site
- disease_is_stage
