Preferred Label : Deuteporfin;
NCIt definition : A photosensitizing agent composed of four sub-porphyrin derivatives, methoxyethy-hydroxyethyl-dipropionic,
di-methoxyethyl-dipropionic, hydroxyethy-vinyl-dipropionic and methoxyethy-vinyl-dipropionic,
with potential photosensitizing activity upon photodynamic therapy (PDT) and potential
diagnostic imaging activity. Upon intravenous administration, deuteporfin preferentially
targets and accumulates in cancer cells, especially those in the lymphatic system.
Following photoactivation with an appropriate wavelength, deuteporfin generates highly
cytotoxic singlet oxygen species, and induces oxidative stress that results in the
damage and death of cancer cells. In addition, deuteporfin could be used as a tracer
in near-infrared (NIR) fluorescence lymph node mapping.;
NCI Metathesaurus CUI : CL519824;
Origin ID : C132685;
UMLS CUI : C4329719;
Semantic type(s)
- concept_is_in_subset
