Preferred Label : H3.3K27M-specific Peptide Vaccine;
NCIt synonyms : H3.3K27M Peptide Vaccine;
NCIt definition : A vaccine composed of a peptide derived from histone H3.3 containing the amino acid
substitution mutation lysine (Lys) 27-to-methionine (H3.3K27M), with potential immunoactivating
and antineoplastic activities. Upon administration of the H3.3K27M-specific peptide
vaccine, the immune system may exert a cytotoxic T-lymphocyte (CTL)-mediated immune
response against H3.3K27M-expressing tumor cells. The H3.3K27M mutation alters the
methylation and acetylation profile of the histone H3 variant H3.3 at Lys 27. Modification
of H3.3 at Lys 27 regulates gene expression, and the H3.3K27M mutation occurs in a
variety of cancer cell types.;
NCI Metathesaurus CUI : CL519856;
Origin ID : C132684;
UMLS CUI : C4330062;
Semantic type(s)
- concept_is_in_subset
- has_target
