NCIt definition : A synthetic cyclic dinucleotide (CDN) and agonist of stimulator of interferon genes
protein (STING), with potential immunoactivating and antineoplastic activities. Upon
intratumoral (IT) administration,ulevostinag binds to STING and activates the STING
pathway, which promotes IKK-related kinase TANK-binding kinase 1 (TBK1) signaling
and activates nuclear factor-kappa B (NF-kB) and interferon regulatory factor 3 (IRF3)
in immune cells in the tumor microenvironment; this leads to the production of pro-inflammatory
cytokines, including interferons (IFNs). Specifically, expression of IFN-beta (IFNb)
enhances the cross-presentation of tumor-associated antigens by CD8alpha-positive
and CD103-positive dendritic cells (DCs) to cytotoxic T-lymphocytes (CTLs). This results
in a CTL-mediated immune response against tumor cells and causes tumor cell lysis.;
Semantic type(s)