" /> Muromonab-CD3 - CISMeF





Preferred Label : Muromonab-CD3;

NCIt synonyms : Anti-CD3 Monoclonal Antibody OKT3; Monoclonal Antibody OKT3; MoAb OKT3;

NCIt related terms : muromonab-CD3 monoclonal antibody;

NCIt definition : A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3 binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell subset, followed by cytokine release, and subsequently inhibition of T cell functions. This agent may cause the opsonization and elimination of CD3-positive T cells from the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of the functional T cell receptor (TCR) complex, which is necessary for antigen recognition by T cells, and is required for signal transduction.;

Alternative definition : NCI-GLOSS: A type of monoclonal antibody used in cancer detection or therapy. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.;

UNII : JGA39ICE2V;

CAS number : 140608-64-6;

Drug name : Orthoclone OKT3;

NSC code : 618843;

Codes from synonyms : CDR0000046732;

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29/05/2025


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