NCIt related terms : muromonab-CD3 monoclonal antibody;
NCIt definition : A murine IgG2a monoclonal antibody with immunosuppressive activity. Muromonab-CD3
binds to and inhibits CD3 on the surface of circulating T-lymphocytes; binding of
muromonab-CD3 to CD3-positive T cells results in an early activation of this T cell
subset, followed by cytokine release, and subsequently inhibition of T cell functions.
This agent may cause the opsonization and elimination of CD3-positive T cells from
the circulation by mononuclear phagocytes in the liver and spleen. CD3 is part of
the functional T cell receptor (TCR) complex, which is necessary for antigen recognition
by T cells, and is required for signal transduction.;
Alternative definition : NCI-GLOSS: A type of monoclonal antibody used in cancer detection or therapy. Monoclonal
antibodies are laboratory-produced substances that can locate and bind to cancer cells.;