Preferred Label : Gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907;
NCIt synonyms : 68Ga-NODAGA-Ac-Cys-ZEGFR:1907; [68Ga]-labeled Anti-EGFR Affibody Molecule Ac-Cys-ZEGFR:1907; Gallium Ga 68-NODAGA-Ac-Cys-Z(EGFR:1907);
NCIt definition : A radiolabeled recombinant EGFR-specific affibody molecule composed of an epidermal
growth factor receptor (EGFR)-targeting protein, the anti-EGFR affibody ZEGFR:1907
with an acetylated cysteine (Ac-Cys) at the N terminal of the affibody, and conjugated
to the radioisotope gallium Ga 68, via the chelating agent NODAGA (1,4,7-triazacyclononane,1-glutaric
acid-4,7-acetic acid), with potential use for imaging EGFR-expressing tumor cells
upon positron emission tomography (PET). Upon administration of gallium Ga 68-NODAGA-Ac-Cys-ZEGFR:1907,
the ZEGFR:1907 affibody molecule moiety targets and binds to the extracellular domain
(ECD) of EGFR expressed on various tumor cell types. Upon PET, EGFR-expressing tumor
cells can be visualized. EGFR, frequently overexpressed in cancers, plays important
roles in cell proliferation, survival, adhesion, migration, and differentiation. The
affibody protein scaffold is based on the Z-domain, which is derived from one of the
immunoglobulin (Ig) G-binding domains of staphylococcal protein A.;
NCI Metathesaurus CUI : CL520663;
Origin ID : C132029;
UMLS CUI : C4330032;
Semantic type(s)
- concept_is_in_subset
