Preferred Label : EGFR T790M Antagonist BPI-15086;
NCIt synonyms : EGFR T790M Inhibitor BPI-15086;
NCIt definition : An orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant
form T790M, with potential antineoplastic activity. EGFR T790M antagonist BPI-15086
specifically binds to and inhibits EGFR T790M, a secondarily acquired resistance mutation,
which prevents EGFR-mediated signaling and leads to cell death in EGFR T790M-expressing
tumor cells. EGFR, a receptor tyrosine kinase that is mutated in many tumor cell types,
plays a key role in tumor cell proliferation and tumor vascularization.;
Molecule name : BPI-15086; BPI 15086;
NCI Metathesaurus CUI : CL520366;
Origin ID : C131909;
UMLS CUI : C4329761;
Semantic type(s)
- concept_is_in_subset
- has_target
