NCIt definition : A topical nanoemulsion-based gel formulation containing 5-aminolevulinic acid (ALA),
a metabolic precursor of the photosensitizer protoporphyrin IX, with a potential application
for enhanced photodynamic therapy (PDT) for various precancerous and malignant skin
lesions. After topical administration of a thick layer of the ALA-based BF-200 gel
formulation to the affected area, ALA penetrates the skin and is intracellularly converted
to protoporphyrin IX (PpIX). Exposure of PpIX to the proper excitation wavelength
of light generates singlet oxygen molecules, resulting in a local cytotoxic effect.;
Currated CISMeF NLP mapping