Preferred Label : Gallium Ga 68-NOTA-3PTATE-RGD;
NCIt synonyms : 68Ga-NOTA-3PTATE-RGD;
NCIt definition : A radiopharmaceutical agent composed of a modified form of the somatostatin analogue
octreotate (TATE), linked, via a glutamate linker, to the cyclic tri-amino acid arginine-glycine-aspartic
acid (RGD) motif (3PTATE-RGD), and labeled, via the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA) with the radioisotope gallium Ga 68, with potential somatostatin receptor
type 2 (SSTR2) and alphaVbeta3 (aVb3) integrin imaging activity upon positron emission
topography (PET) or single photon emission computed tomography (SPECT). After intravenous
administration, gallium Ga 68-NOTA-3PTATE-RGD simultaneously binds to SSTR, with its
TATE moiety (with a preference for SSTR2), and to the integrin receptor aVb3 with
its RGD moiety. Both SSTR2 and aVb3 are expressed on the membrane of certain tumor
cells while minimally or not expressed on healthy, normal cells. Upon PET imaging,
SSTR2- and aVb3 integrin-expressing tumor cells can be visualized and expression levels
can be quantified. SSTR2 and aVb3 play key roles in tumor proliferation and survival.;
NCI Metathesaurus CUI : CL520666;
Origin ID : C131904;
UMLS CUI : C4330035;
Semantic type(s)
- concept_is_in_subset
