Preferred Label : VDAC/HK2 Modulator Ointment VDA-110;
NCIt synonyms : VDA-1102 Topical Dermal Ointment; VDA-1102 Ointment;
NCIt definition : A topical ointment formulation containing a voltage-dependent anion channel (VDAC)/hexokinase
2 (HK2) modulator, with potential activity against certain skin cancers. Upon topical
application, VDA-1102, as a protein-protein interaction (PPI) disrupter, allosterically
binds to HK2, and causes HK2 to dissociate from VDAC, which prevents glycolysis and
triggers apoptosis, thereby inhibiting tumor cell growth in VDAC/HK2-expressing tumor
cells without affecting the surrounding healthy skin tissue. The VDAC/HK2 system,
over-activated in cancer cells, plays a key role in tumor cell proliferation. The
VDAC/HK2 association protects cancer cells from apoptosis. HK2 is overexpressed in
many malignant cancer tissues that rely on glycolysis, while its expression is limited
in normal healthy cells.;
Molecule name : VDA-1102;
NCI Metathesaurus CUI : CL514459;
Origin ID : C131826;
UMLS CUI : C4331489;
Semantic type(s)
- concept_is_in_subset
