Preferred Label : Adenovirus-expressing TLR5/TLR5 Agonist Nanoformulation M-VM3;
NCIt synonyms : Mobilan;
NCIt definition : A nanoparticle-based formulation containing a recombinant non-replicating adenovirus
(Ad) encoding toll-like receptor 5 (TLR5) and its specific ligand protein 502S, with
potential antineoplastic and immunomodulating activities. Upon administration, the
Ad preferentially and specifically infects cells expressing the Coxsackievirus and
adenovirus receptor (CAR), which is highly expressed in certain human tumors, and
expresses both TLR5 and a specific agonistic ligand in the same cell. 502S binds to
and activates TLR5, thereby allowing for continuous TLR5 signaling. This stimulates
dendritic cells (DCs), monocytes, macrophages and the nuclear factor-kappa B (NF-kappaB)
signaling cascade. This activation results in the production of pro-inflammatory cytokines,
including interferon alpha, tumor necrosis factor-alpha and the interleukins (IL),
IL-1 beta, -6 and -12. This may induce a T helper cell-1 (Th1) immune response and
activate a cytotoxic T-lymphocyte (CTL) response against tumor associated antigens
(TAAs). TLR5, a member of the TLR family, plays a key role in the activation of innate
immunity.;
Molecule name : M-VM3;
Origin ID : C131825;
UMLS CUI : C4329277;
Semantic type(s)
- concept_is_in_subset
