Preferred Label : Modified Vitamin D Binding Protein Macrophage Activator EF-022;
NCIt synonyms : Modified VDBP-Macrophage Activator EF-022; MVDP-Macrophage Activator;
NCIt definition : A modified version of vitamin D binding protein (VDBP; Gc protein) macrophage activator,
with potential antineoplastic and anti-angiogenic activities. Upon administration,
modified VDBP-macrophage activator EF-022, acting in a similar manner as VDBP-macrophage
activating factor (GcMAF), is able to activate tumoricidal macrophages, thereby enhancing
the killing and eradication of cancer cells. In addition, EF-022 may inhibit tumor
cell proliferation, migration and angiogenesis. VDBP is a glycoprotein and precursor
for macrophage activating factor (MAF), which promotes macrophage activation; however
VDBP can be deglycosylated by serum alpha-N-acetylgalactosaminidase, which is secreted
from cancerous cells, and cannot be converted to MAF. Thus, the macrophage activation
cascade is often impaired in tumor cells and plays a key role in tumor immunosuppression.
Modification of VDBP stabilizes MAF.;
Molecule name : EF-022;
NCI Metathesaurus CUI : CL514564;
Origin ID : C131824;
UMLS CUI : C4330700;
Semantic type(s)
- concept_is_in_subset
