Oxidopamine - CISMeF

Preferred Label : Oxidopamine;

NCIt synonyms : 6-Hydroxydopamine; 2,4,5-Trihydroxyphenethylamine; 5-(2-Aminoethyl)-1,2,4-benzenetriol; 6-OHDA;

NCIt definition : An antagonist of the neurotransmitter dopamine with potential antineoplastic activity. 6-Hydroxydopamine (6-HOD) can be taken up by selective adrenergic terminals, thereby causing acute degeneration of adrenergic terminals that leads to depletion of norepinephrine, and of dopamine in the dopamine-sensitive sites. This agent is auto-oxidated at physiological pH that leads to the formation of reactive free radicals, thereby leading to cytotoxicity in neural cells. 6-Hydroxydopamine is often used to induce CNS and sympathetic neural lesions that model aging and various nervous disorders in animal systems.;

UNII : 8HW4YBZ748;

InChIKey : DIVDFFZHCJEHGG-UHFFFAOYSA-N;

CAS number : 1199-18-4;

Chemical formula : C8H11NO3;

NSC code : 233898;

Codes from synonyms : NSC0233898; 00640;

PubMed : 2511086;

Details

Origin ID

C1316;

UMLS CUI

C0085196;

Currated CISMeF NLP mapping
- oxidopamine [Substance BNPC]
- oxidopamine [MeSH Descriptor]
- oxidopamine [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- oxidopamine [Substance BNPC]
- oxidopamine [MeSH concept]
- oxidopamine [MeSH Descriptor]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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