Preferred Label : Recombinant Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide
Symporter;
NCIt synonyms : VSV-expressing hIFNb and NIS; VSV-hIFNb-NIS; Vesicular Stomatitis Virus-expressing Human Interferon Beta and Sodium-Iodide Symporter; Oncolytic VSV-hIFNbeta-NIS; VV1; VSV-hIFNbeta-NIS;
NCIt definition : A recombinant, replication competent form of the oncolytic RNA virus vesicular stomatitis
virus (VSV), based on the Indiana strain of VSV, that is genetically engineered to
express the genes for the human cytokine interferon beta (IFNbeta) and the human thyroidal
sodium-iodide symporter (NIS), with potential oncolytic and imaging activities. Upon
intravenous administration, VSV-hIFNbeta-NIS is preferentially taken up by tumor cells,
resulting in tumor cell infection, viral replication and a direct virus-mediated cytolytic
effect against the infected tumor cells. IFN-mediated signaling is defective in tumor
cells and tumor cells are unable to exert an anti-viral response against VSV. As normal,
healthy cells secrete and respond normally to IFNbeta and are able to activate IFN-mediated
anti-viral pathways, the expressed IFNbeta from the VSV-infected tumor cells helps
protect normal cells from VSV infection. Upon subsequent administration of certain
isotope-containing imaging agents, NIS expression by the infected tumor cells allows
visualization and tracking of VSV biodistribution, and analysis and quantification
of VSV-infected tumor cells by positron emission tomography (PET). Also, upon subsequent
administration of the radioisotope iodine I 131 (I131), I131 can be taken up by NIS
and allows for a cytotoxic dose of radiation to accumulate in the NIS-expressing VSV-infected
tumor cells, which also leads to tumor cell death.;
Drug name : Voyager-V1;
NCI Metathesaurus CUI : CL514461;
Origin ID : C131580;
UMLS CUI : C4331494;
Semantic type(s)
- concept_is_in_subset
