NCIt definition : Human FOXC1 wild-type allele is located in the vicinity of 6p25 and is approximately
4 kb in length. This allele, which encodes forkhead box protein C1, is involved in
both embryogenesis and eye development. Mutations in this gene are associated with
Peters anomaly, primary congenital glaucoma, autosomal dominant iridogoniodysgenesis
type 1, and Axenfeld Rieger syndrome 3.;
NCIt note : Aberrant expression of the FOXC1 gene is associated with aggressive disease in 20%
of acute myeloid leukemia (AML) patients. (Cancer Cell, 2015; 28: 329-342.);