Childhood Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A

Preferred Label : Childhood Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A;

NCIt synonyms : Childhood Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A Fusion; Childhood AML with t(11;15)(p15;q35); NUP98::JARID1A; Childhood AML with t(11;15)(p15;q35); NUP98-JARID1A; Childhood Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98::JARID1A Fusion;

NCIt related terms : Acute Myeloid Leukemia with t(11;15)(p15;q35); NUP98-JARID1A; AML with t(11;15)(p15;q35); NUP98-JARID1A;

NCIt definition : Acute myeloid leukemia with a cytogenetically cryptic fusion of NUP98 to JARID1A, t(11;15)(p15;q35). It typically has a megakaryocytic phenotype and occurs in 10% of pediatric, non-Down syndrome-related acute megakaryoblastic leukemia cases.;

Alternative definition : NICHD: Acute myeloid leukemia (AML) with a cytogenetically, cryptic fusion of NUP98 to JARID1A, t(11;15)(p15;q35). It typically has an megakaryocytic phenotype and occurs in 10% of pediatric, non-Down Syndrome-related acute megakaryoblastic leukemia (AMKL) cases.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL514480;

Détails

Origin ID

C131504;

UMLS CUI

C5854747;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- NUP98 Gene Rearrangement [NCIt concept]
- t(11;15)(p15;q35) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Childhood Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- NUP98 Gene [NCIt concept]

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