Childhood Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98-NSD1

Preferred Label : Childhood Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98-NSD1;

NCIt synonyms : Childhood AML with t(5;11)(q35;p15); NUP98-NSD1; Childhood Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98::NSD1 Fusion; Childhood AML with t(5;11)(q35;p15); NUP98::NSD1; Childhood Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98-NSD1 Fusion;

NCIt related terms : AML with t(5;11)(q35;p15); NUP98-NSD1; Acute Myeloid Leukemia with t(5;11)(q35;p15); NUP98-NSD1;

NCIt definition : Acute myeloid leukemia with often cytogenetically cryptic fusion of NUP98 (chromosome 11p15) with NSD1 (chromosome 5q35). This alteration occurs in 4% of pediatric AML cases.;

Alternative definition : NICHD: Acute myeloid leukemia (AML) with often cytogenetically cryptic fusion of NUP98 (chromosome 11p15) with NSD1 (chromosome 5q35). This alteration occurs in 4% of pediatric AML cases.;

Neoplastic status : Malignant;

NCI Metathesaurus CUI : CL514481;

Détails

Origin ID

C131502;

UMLS CUI

C5854746;

Disease excludes abnormal cell
- Neoplastic Lymphoblast [NCIt concept]
Disease excludes normal cell origin
- Lymphocyte [NCIt concept]
Disease may have findings
- Hypercellular Bone Marrow [NCIt concept]
Has associated anatomic sites
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
Has cytogenetic abnormalities
- Chromosomal Rearrangement [NCIt concept]
- NUP98 Gene Rearrangement [NCIt concept]
- t(5;11)(q35;p15) [NCIt concept]
Semantic type(s)
- Neoplastic Process [UMLS semantic type]
concept_is_in_subset
- NICHD Terminology [NCIt concept]
- Pediatric Hematology-Oncology Terminology [NCIt concept]
disease_excludes_finding
- Benign Cellular Infiltrate [NCIt concept]
- Chronic Clinical Course [NCIt concept]
- Cytogenetic Abnormalities Not Detected [NCIt concept]
- Solid Growth Pattern [NCIt concept]
disease_has_abnormal_cell
- Leukemic Cell [NCIt concept]
- Malignant Cell [NCIt concept]
- Neoplastic Cell [NCIt concept]
- Neoplastic Hematopoietic and Lymphoid Cell [NCIt concept]
- Neoplastic Myeloblast [NCIt concept]
- Neoplastic Myeloid Cell [NCIt concept]
disease_has_finding
- Blasts 10 Percent or More of Bone Marrow Nucleated Cells [NCIt concept]
- Blasts 10 Percent or More of Peripheral Blood White Cells [NCIt concept]
- Childhood Lesion [NCIt concept]
- Malignant Cellular Infiltrate [NCIt concept]
- Recurrent Genetic Abnormalities Present [NCIt concept]
disease_has_molecular_abnormality
- Fusion Protein Expression [NCIt concept]
disease_has_normal_cell_origin
- Bone Marrow Stem Cell [NCIt concept]
- Hematopoietic and Lymphoid Cell [NCIt concept]
disease_has_normal_tissue_origin
- Hematopoietic Tissue [NCIt concept]
- Hematopoietic and Lymphoid Tissue [NCIt concept]
disease_has_primary_anatomic_site
- Bone Marrow [NCIt concept]
- Hematopoietic and Lymphatic System [NCIt concept]
disease_mapped_to_gene
- NUP98 Gene [NCIt concept]
- NUP98/NSD1 Fusion Gene [NCIt concept]
pathogenesis_of_disease_involves_gene
- NUP98/NSD1 Fusion Gene [NCIt concept]

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