Preferred Label : Fluorine F 18 ODS2004436;
NCIt synonyms : 18F-ODS2004436; [18F]-ODS2004436;
NCIt definition : A radioconjugate containing the epidermal growth factor receptor (EGFR) kinase tracer
ODS2004436 labeled with fluorine F 18 for potential tumor imaging using positron emission
tomography (PET). Upon administration of fluorine F 18 ODS2004436, the ODS2004436
moiety selectively targets and binds to forms of EGFR that contain activating mutations.
This allows the visualization of tumor cells expressing activating EGFR mutations
using PET. This agent can also be utilized in the prediction of responsiveness to
EGFR tyrosine kinase inhibitors (TKIs) and the selection of patients that respond
well to those kinase inhibitors that specifically target forms of EGFR with activating
mutations. EGFR-activating mutations play a key role in the development of certain
tumors and in tumor resistance to a variety of antineoplastic agents.;
NCI Metathesaurus CUI : CL514285;
Origin ID : C131497;
UMLS CUI : C4329996;
Semantic type(s)
- concept_is_in_subset
