Preferred Label : Anti-androgen siRNA SXL01;
NCIt definition : A small-interfering RNA (siRNA) directed against androgen receptor (AR), with potential
antineoplastic activity. Upon administration of anti-AR siRNA SXL01, the siRNAs bind
to AR mRNAs, which may result in the inhibition of translation of the AR protein.
By preventing AR expression, AR-mediated signaling is decreased, which leads to growth
inhibition for AR-expressing tumor cells. AR, overexpressed in a variety of cancers,
is involved in cellular proliferation and survival.;
Molecule name : SXL 01; SXL-01;
NCI Metathesaurus CUI : CL514247;
Origin ID : C131496;
UMLS CUI : C4329342;
Semantic type(s)
- concept_is_in_subset
