Preferred Label : Ruserontinib;
NCIt synonyms : Multikinase Inhibitor SKLB1028; 9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine; 9H-Purine-2,8-diamine, 9-(1-Methylethyl)-N2-[4-(4-methyl-1-piperazinyl)phenyl]-N8-3-pyridinyl-; EGFR/FLT3/Abl Inhibitor SKLB1028;
NCIt definition : An orally available inhibitor of epidermal growth factor receptor (EGFR), FMS-related
tyrosine kinase 3 (FLT3, STK1, CD135 or FLK2), and the non-receptor tyrosine kinase
ABL (Abl), with potential antineoplastic activity. Upon administration, ruserontinib
specifically binds to and inhibits EGFR, FLT3 and Abl, which interferes with the activation
of EGFR-, FLT3- and Abl-mediated signal transduction pathways and reduces cell proliferation
in cancer cells that overexpress EGFR, FLT3 and/or Abl. EGFR, EGFR and Abl are all
overexpressed in a variety of cancers and play key roles in tumor cell proliferation.;
UNII : AQ3TTU8UM7;
CAS number : 1350544-93-2;
Molecule name : SKLB 1028; SKLB-1028;
Origin ID : C131492;
UMLS CUI : C5783365;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
