Preferred Label : Ceramide Nanoliposome;
NCIt synonyms : CNL; Nanoliposomal Ceramide;
NCIt definition : A lipid-based nanoparticle formulation composed of the apoptosis-inducing sphingolipid
ceramide encapsulated within nanoliposomes, with potential apoptotic and antineoplastic
activities. Upon administration, ceramide nanoliposomes accumulate in the tumor environment,
due to the unique properties of the tumor vasculature, and easily enter tumor cells.
This delivers ceramide inside the tumor cells, where ceramide induces apoptosis. Although
the process is not completely understood, ceramide-dependent apoptosis most likely
results from the downregulation of nutrient transporter proteins, which prevents cellular
access to extracellular nutrients and causes tumor cell starvation. This selectively
destroys tumor cells. Ceramide alone is insoluble and has a very short half-life;
therefore, the nanoliposome formulation increases its solubility and half-life. Ceramide
plays a key role in the regulation of autophagy, apoptosis, survival and proliferation.
Serving as a tumor suppressor lipid, the expression of ceramide is inversely correlated
with tumor cell growth, survival and metastasis.;
Molecule name : KN 001; KN-001; KN-01;
NCI Metathesaurus CUI : CL514701;
Origin ID : C131434;
UMLS CUI : C4321475;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- concept_is_in_subset
