Preferred Label : Oligomeric Procyanidin Complex;
NCIt synonyms : Oligomeric Flavanols; Oligomeric Proanthocyanidins; Oligomeric Procyanidolic Complex; OPC;
NCIt definition : A preparation containing plant-derived polyphenolic bioflavonoids composed of multimers
(dimers, trimers, or higher order polymers) of the flavan-3-ol-based monomers catechin
and epicatechin, which are extracted from sources rich in these chemicals, such as
grape seeds, grape skin and pine bark, with potential anti-oxidant, anti-inflammatory,
anti-microbial, anti-cancer and protective activities. Upon oral administration of
oligomeric procyanidin complex (OPC), the polyphenols exert anti-oxidant activity
by scavenging free radicals, which prevents both the formation of reactive oxygen
species (ROS), particularly nitrous oxide (NO), and DNA damage. OPC also inhibits
chemical-induced lipid peroxidation. In addition, OPC reduces the production advanced
glycation end-products (AGE), decreases AGE accumulation in tissues, and inhibits
the progression of AGE/receptor for AGE (RAGE)-mediated inflammatory transduction
pathways, which inhibits the activation of pro-inflammatory transcriptional regulators
and prevents the secretion of pro-inflammatory cytokines/chemokines. This ultimately
prevents inflammatory-driven damage to end organs and may reduce inflammation-induced
cancer formation and progression. In addition, OPC inhibits the activity of a variety
of enzymes, including xanthine oxidase, collagenase, elastase hyaluronidase and beta-glucuronidase.;
NCI Metathesaurus CUI : CL514533;
Origin ID : C131333;
UMLS CUI : C4330852;
Semantic type(s)
- concept_is_in_subset
